Chemotherapy was potentiated by E7449 and one agent had considerable antitumor action in BRCA-deficient xenografts. Also, E7449 inhibited Wnt/β-catenin signaling in colon most cancers cell lines, most likely through TNKS inhibition. According to this risk, E7449 stabilized axin and TNKS proteins resulting in β-catenin de-stabilization and noticeably altered expression of https://saeedn776jct8.newbigblog.com/profile