Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts from the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have determined recurrent mutations in genes regulating tumor mobile-microenvironment interaction... https://shintaroc096xfo3.tusblogos.com/profile