Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals in the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have discovered recurrent mutations in genes regulating tumor mobile-microenvironment interactions, w... https://yasunarix753pwf0.ourcodeblog.com/profile