Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts with the microenvironment and growing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have determined recurrent mutations in genes regulating tumor mobile-microenvironment interactions, whic... https://scottj544btk4.fare-blog.com/profile