Limb-threatening or important limb ischemia (CLI) is manifested by Long-term (greater than two months) ischemic rest pain, ischemic wounds or tissue decline, or gangrene in a single or the two legs. Ischemic relaxation discomfort typically occurs quickly just after falling asleep; the individual is awakened by burning discomfort or numbness https://www.sgvascularctr.com/treatment-of-peripheral-artery-disease-pad-in-singapore-a-comprehensive-guide/