Tapentadol is partly metabolized by the hepatic enzymes CYP2C9, CYP2C19, and CYP2D6 so it innately has interactions with medications that greatly enhance or repress the action/expression of one or more of these enzymes, and with substrates of those enzymes (as a consequence of Levels of competition for that enzyme); some https://chep197ydg0.sasugawiki.com/user